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Atorvastatin Calcium Form 1
New Crystalline Solvates of Atorvastatin Calcium – Wiley Online is marketed as its calcium salt. (see Fig. 1) in crystalline trihydrate designated form I (Lipi- tor ; Warner-Lambert, now Pfizer) 6 . Lipitor has become the world 39;s best-selling nbsp; US7468444B2 – Crystal forms of atorvastatin hemi-calcium and hemi-calcium Form VI is characterized by a powder X-ray diffraction pattern ( FIG. 1 ) with peaks at 3. 5, 5. 1, 7. 7, 8. 2, 8. 7, 10. 0, 12. 5, 13. 8, 16. 2, 17. 2, 17. 9 18. 3, 19. 5, 20. 4, 20. 9, 21. 7, 22. 4, 23. 2, 24. 3, 25. 5 0. 2 degrees two-theta. The most characteristic peak is observed at 19. 5 0. 2 degrees two-theta. The PXRD nbsp; Process for the production of atorvastatin calcium in amorphous form of the hemi-calcium salt of (3r, 5r) 7- 3-phenyl-4-phenylcarbamoyl-2-(4-fluorophenyl)-5-isopropyl-pyrrol-1-yl!-3, 5-dihydroxyheptanoic acid (atorvastatin). EP1577297A1 2004-03-17 2005-09-21 Ranbaxy Laboratories, nbsp; Atorvastatin Calcium quot;Form 1 quot; quot;Form 1 quot;. Martin Vickers. 11<sup>th</sup> Oct 2008. Experimental Data. Click image to access powder diffraction data (. spf format). Chemical Name. (3R, 5R)-7- 2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl -3, 5-dihydroxyheptanoic acid, calcium salt (2:1) trihydrate. Atorvastatin calcium C66H74CaF2N4O13 – PubChem C66H74CaF2N4O13 CID 656846 – structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, calcium;(3R, 5R)-7- 2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl -3, 5-dihydroxyheptanoate;trihydrate. from PubChem nbsp; Atorvastatin calcium C66H68CaF2N4O10 – PubChem is a pyrrole and heptanoic acid derivative, HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITOR (statin), and ANTICHOLESTEREMIC AGENT that is used to reduce serum levels of LDL-CHOLESTEROL; APOLIPOPROTEIN B; AND TRIGLYCERIDES and to increase serum levels of nbsp; Atorvastatin – Wikipedia , marketed under the trade name Lipitor among others, is a member of the medication class known as statins, which are used primarily as a lipid-lowering agent and for prevention of events associated with cardiovascular disease. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme nbsp; Atorvastatin Calcium USP-NF of the drug substance, namely an amorphous form, semicrystalline form, and the propylene glycol solvate form of atorvastatin calcium are added to the monograph. The System suitability requirements under Organic Impurities, Procedure 1, which were inadvertently omitted, are now included. WO2002083638A1 – Process for the production of atorvastatin like other prior arts. However conversion of form– 1 of atorvastatin calcium in to amorphous atorvastatin calcium disclosed herein is an additional procedure within the scope of the present invention to exploit on nbsp; Preparation of stable new polymorphic form of atorvastatin calcium (1) is a member of the class of drugs called statins. Statin drugs are currently the most therapeutically effective drugs available for reducing low density lipoprotein. (LDL) particle concentration in the blood stream of patients at risk for cardiovascular disease. A high level of LDL in the blood stream has nbsp;
Preparation of amorphous atorvastatin calcium from – myExperiment
. Abstract: The present invention relates to the process for the preparation of amorphous form of. Atorvastatin calcium which comprises the . Detailed Description of the Invention: Preparation of amorphous Atorvastatin calcium: Example 1: Crystalline atorvastatin calcium (0. 5gm) was dissolved in 1, nbsp; Atorvastatin (calcium salt) (CAS 134523-03-8) Cayman Chemical is an HMG-CoA reductase inhibitor (IC50 154 nM) that is effective in treating hypercholesterolemia and certain dyslipidemias. 1, 2, 3 It may also be used to prevent coronary or stroke events in hypertensive patients with normal cholesterol levels. <sup>4</sup> In addition to inhibiting cholesterol synthesis, atorvastatin nbsp; LIPITOR (atorvastatin calcium) Dosage Forms and Strengths : LIPITOR Tablet Strengths and Identifying Features. Tablet Strength, Identifying Features. 10 mg of atorvastatin, quot;PD 155 quot; on one side and quot;10 quot; on the other. 20 mg of atorvastatin, quot;PD 156 quot; on one side and quot;20 quot; on the other. 40 mg of atorvastatin, quot;PD 157 quot; on one side and quot;40 quot; on the other. 80 mg of atorvastatin, quot;PD nbsp; Patent EP1659110A1 – Process for the production of atorvastatin Process for the production of atorvastatin calcium un amorphous form. EP 1659110 A1. Abstract. A process for the production of amorphous atorvastatin calcium and stabilized, amorphous atorvastatin calcium is provided. Images(4). Patent Drawing. Search Report (1). Patent Drawing. Search Report (2). enhancement of solubility and dissolution rate of different forms of used in the preparation of the direct compression formulas since it was observed that addition of a buffering or alkalizing agent that can provide a pH equal to or greater than (pKa 1), i. e. (pH 6) can enhance both solubility and dissolution rate of atorvastatin calcium nbsp; Development and validation of RP-HPLC method for determination and Nicotinic acid in combined tablet dosage form acid calcium salt trihydrate Fig. 1 (Gennaro, 2000). Atorvastatin selectively and competitively inhibits the hepatic enzyme HMG-CoA reductase. Nicotinic acid is chemically nbsp; Lipitor (Atorvastatin Calcium): Side Effects, Interactions, Warning Atorvastatin calcium is R-(R , R ) -2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4- (phenylamino)carbonyl -1Hpyrrole-1-heptanoic acid, calcium salt (2:1)trihydrate. The empirical formula of atorvastatin calcium is(C33H34FN2O5)2Ca 3H2O and its molecular weight is 1209. 42. Its structural nbsp; Preparation, characterization and in vivo evaluation of – CiteSeerX after oral admin- istration of amorphous atorvastatin calcium nanoparticles to rats was markedly increased. У 2008 Elsevier B. V. All rights reserved. Keywords: Atorvastatin calcium; Supercritical antisolvent; Nanoparticle; Amorphous form. 1. Introduction. Atorvastatin is a selective, nbsp; atorvastatin calcium trihydrate (CHEBI:2911) – EMBL-EBI CHEBI:2911 – atorvastatin calcium trihydrate Definition, A hydrate that is the trihydrate form of atorvastatin calcium. Ca. 3H2O/c2 1– 21(2) 31- 30(33(41) 35- 25- 11- 7- 4- 8- 12- 25) 29(22- 9- 5- 3- 6- 10- 22) 32(23- 13- 15- 24(34) 16- 14- 23) 36(31) 18- 17- 26(37) 19- 27(38) 20- 28(39) 40;;;;/h2 3- 16, 21 nbsp; Solid-State NMR Studies of Form I of Atorvastatin Calcium – The Solid-state <sup>13</sup>C, <sup>19</sup>F, and <sup>15</sup>N magic angle spinning NMR studies of Form I of atorvastatin calcium are reported, including chemical shift tensors of all resolvable carbon sites and fluorine sites. The complete <sup>13</sup>C and <sup>19</sup>F chemical shift assignments are given based on an extensive analysis of <sup>13</sup>C <sup>1</sup>H nbsp; Patent WO2002057274A1 – A process for the synthesis of – Google -methylethyl)-3-phenyl-4- (phenylamino)carbonyl -1H-pyrrole-1-heptanoic acid hemi calcium, atorvastatin form V. The compound so prepared is useful as inhibitors of the enzyme HMG-CoA reductase and nbsp;
Preparation, characterization and in vivo evaluation of – CiteSeerX
after oral admin- istration of amorphous atorvastatin calcium nanoparticles to rats was markedly increased. У 2008 Elsevier B. V. All rights reserved. Keywords: Atorvastatin calcium; Supercritical antisolvent; Nanoparticle; Amorphous form. 1. Introduction. Atorvastatin is a selective, nbsp; Process for the production of atorvastatin calcium – Biocon Limited 20050119493, Process for the preparation of amorphous atorvastin calcium salt (2:1), 2005-06-02, Suri et al. 548/ . WO 97/03958 and WO 97/03959 disclose novel crystalline forms of atorvastatin calcium designated as Form I, Form II, Form III and Form IV and methods for their preparation, providing more nbsp; Spectrophotometric Determination of Atorvastatin Calcium and and Rosuvastatin Calcium in Bulk and Dosage Form Using P-Dimethylaminobenzaldehyde. Sobhy M. Al-Adl, Lobna M. Abdel-Aziz, Maha AM. Mohamed. <sup>1</sup>Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, P. C. 44 519, Zagazig, Egypt. Simultaneous Determination of Atorvastatin Calcium and , No. 4, pp 970-973, Oct-Dec 2009. SIMULTANEOUS DETERMINATION OF ATORVASTATIN. CALCIUM AND TELMISARTAN IN TABLET DOSAGE FORM BY. SPECTROPHOTOMETRY. U. P. PATIL1, S. V. GANDHI1 , M. R. SENGAR1 and V. S. RAJMANE1. 1 Department of Pharmaceutical Analysis, A. I. S. S. M. S. College of nbsp; Simultaneous Estimation of Atorvastatin Calcium – Springer Link . Calcium, Ramipril and Aspirin in Capsule. Dosage Form by RP-LC. Hiral J. Panchal1, amp;, Bhanubhai N. Suhagia2, Natvarlal J. Patel1, Ishwarsinh S. Rathod2, . Bhavesh H. Patel1. 1 Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat Vidyanagar, Ganpat nbsp; Generic Lipitor Is All In The Crystal Forms The Haystack That 39;s when Lipitor, the 1 drug in the world in terms of sales, loses its marketing exclusivity in the U. S. , making it possible for still more generics to get a piece of that pie. What 39;s interesting from a Here is a patent filed in 2001 from Teva for Atorvastatin hemi-calcium form VII. It has a decent discussion of nbsp; Solid-State NMR Studies of Form I of Atorvastatin Calcium – NSF-PAR Various polymorphic forms of pharmaceutical materials typically have Atorvastatin calcium (ATC, see Figure 1), a member of a class of drugs February 23, 2012. Published: February 23, 2012. Figure 1. Molecular structure of atorvastatin, showing the numbering of the carbons and nitrogens. Article. Patent Baristas Pfizer To Get Re-Examination Certificate on Lipitor Claims 1-117 are allowed because they are directed to crystalline forms of atorvastatin which are not found in the prior art. In its response, Pfizer submitted declarations showing the x-ray powder diffraction analysis of the atorvastatin calcium compounds of the prior art as compared to the compounds nbsp; Degradation Kinetics of Atorvastatin under Stress Conditions – MDPI 1. Introduction. Lipitor , the commercial brand name of atorvastatin, was the best selling drug in the World from. 2002 to 2009, generating a gross revenue Atorvastatin calcium (ATV) is used to reduce the levels of lipoproteins rich in cholesterol and . . Gyeong, N. S. ; Taek, S. Y. Crystal forms of atorvastatin.
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